evaluation of human leukocyte antigen-g and interleukin-10 expression in hiv positive patients and healthy subjects
نویسندگان
چکیده
background and purpose: hila-g is an immunomodulatory molecule and alteration of its expression is prevalent during viral infections. hla-g expression in hiv-positive patients has been inconsistent between different studies and some suggest that interleukin-10 (il-10) influences the expression of hla-g. the aim of this research was to investigate the expression of il-10 in hiv-positive patients and its relation with tcd4+ lymphocytes. materials and methods: in a case-control study, 20 hiv-positive patients, attending the behavioral consultation center affiliated with mazandaran university of medical sciences, were selected and 20 healthy volunteers were also enrolled. expression of hla-g was determined by real-time pcr. tcd4+ count and il-10 concentration were evaluated by flow cytometry and elisa, respectively. results: hla-g gene expression was significantly different between the two groups (p<0.05). il-10 concentration increased in patients and a revers relation was seen between tcd4+ cell count and il-10 (r= -0.4, p= 0.1). conclusion: the results showed that the expression of hla-g is deregulated during hiv infection and il-10 could be considered as a biomarker of disease progression.
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عنوان ژورنال:
مجله دانشگاه علوم پزشکی مازندرانجلد ۲۶، شماره ۱۴۳، صفحات ۲۳۰-۲۳۴
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